What this page covers: the two published preprints of the PMCHS framework, with their DOI. For version history and revisions, see Previous versions / archives.
Published preprints
Preprint · Zenodo / OSF · April 2026
Programmed Mast Cell Hyperreactivity Syndrome (PMCHS): An Epigenetically Programmed Trans-Diagnostic Framework Linking Early Adversity, Mast Cell Dysregulation and Chronic Multisystem Disease
Full theoretical framework of PMCHS: mechanistic model centred on the NR3C1/KITLG axis, four degranulation phenotypes, international survey data (N=423), transgenerational transmission hypothesis and comorbidity mapping. Not yet peer-reviewed.
Preprint · Zenodo / OSF · June 2026
PMCHS and Primitive Reflexes: Mast Cell Disruption of Synaptic Pruning, Locus Coeruleus and Neonatal Neuromotor Development
This preprint formalises the link between transmitted maternal PMCHS terrain, disrupted synaptic pruning via microglial activation, locus coeruleus hyperactivation, and non-integration of primitive reflexes as an early neurodevelopmental marker. Includes the neonatal GIH hypothesis as a third mechanistic pathway to SIDS. Not yet peer-reviewed. A version 4 is in preparation — see the version archive.
