Published preprints
Programmed Mast Cell Hyperreactivity Syndrome (PMCHS): An Epigenetically Programmed Trans-Diagnostic Framework Linking Early Adversity, Mast Cell Dysregulation and Chronic Multisystem Disease
Full theoretical framework of PMCHS/SHMP: mechanistic model centred on the NR3C1/KITLG axis, four degranulation phenotypes, international survey data (N=423), transgenerational transmission hypothesis and comorbidity mapping. Not yet peer-reviewed.
PMCHS and Primitive Reflexes: Mast Cell Disruption of Synaptic Pruning, Locus Coeruleus and Neonatal Neuromotor Development
This preprint formalises the link between transmitted maternal PMCHS terrain, disruption of synaptic pruning via microglial activation, locus coeruleus hyperactivation and non-integration of primitive reflexes as an early neurodevelopmental marker of the PMCHS terrain. Includes the neonatal GIH hypothesis as a third mechanistic pathway to SIDS. Not yet peer-reviewed.
Scientific presentations
PMCHS & SIDS — A maternal mast cell terrain as a risk factor for Sudden Infant Death Syndrome
Presentation of the PMCHS/SIDS hypothesis to clinicians and researchers specialising in neuroinflammatory diseases and immunopathologies. Four degranulation phenotypes, SIDS signal (9.7%), vagal tone, primitive reflexes and neonatal GIH as convergent mechanistic pathways.
📄 Download one-pager - only FRInternational Symposium on Mast Cells and Stem Cells — PMCHS Poster
Poster accepted for presentation session at ISMCAS 2027 (Minnesota). Confirmation received from Laurie Radovsky.
International survey 2026
Convergent signals
42.1% report exclusively maternal transmission. The maternal-to-paternal ratio stands at 5.4:1 — consistent with epigenetic inheritance along the maternal line. Only 7.8% report exclusively paternal transmission.
79.3% of respondents who answered this item report significant stressful or traumatic events during childhood (ages 0–18) — converging with scientific data on HPA axis programming and NR3C1 methylation.
94.8% experienced difficulties before receiving appropriate care. 42.3% waited more than 15 years. 94.5% have never had their urinary histamine measured.
79.9% of respondents report at least one first-degree family member with similar conditions. 9.7% report a SIDS history in their family or close circle — a signal warranting formal investigation.
Research notes
What is PMCHS, and why does it need a new name?
Millions of people live with conditions labelled"without known cause". This note explains why mast cells may be the missing link, and what the word"programmed" changes in how we understand these illnesses.
Read the note →Sudden infant death: what if the maternal terrain played a role?
9.7% of survey respondents report a SIDS history in their family. This note explores the possible link between mast cell hyperreactivity and SIDS, and calls for formal investigation.
Read the note →Lipedema: why diets don't work, and what mast cells have to do with it
Lipedema affects around 11% of women and is almost always misdiagnosed. This note describes how mast cell inflammation, amplified by estrogen, creates a pathological adipose tissue resistant to any conventional approach.
Read the note →Refractory obesity: when chronic inflammation short-circuits willpower
Some forms of obesity don't respond to conventional approaches because they are driven by mast cell inflammation in adipose tissue. This note explains the mechanism and its therapeutic implications within the PMCHS terrain framework.
Read the note →Kounis syndrome, POTS, arrhythmias: the heart under mast cell influence
Unexplained palpitations, orthostatic intolerance, or cardiac reactions during an allergic episode may share a common root: easily activated cardiac mast cells.
Read the note →Refractory asthma and sleep apnea: when mast cells obstruct breathing
Asthma resistant to bronchodilators, sleep apnea without obvious obesity, unexplained bronchospasms — these presentations may stem from bronchial and laryngeal mast cell activation.
Read the note →Chronic urticaria, hidradenitis suppurativa, rosacea: skin as an expression terrain
These three chronic skin conditions share a central mechanism: local mast cell activation amplified by stress, hormones, and certain foods.
Read the note →Refractory depression, chronic anxiety, PTSD: what if it were also inflammatory?
Some psychiatric presentations don't respond to standard antidepressants because they are partly sustained by mast cell neuroinflammation.
Read the note →Infant colic: when"it will pass" is not an answer
So-called"functional" colic affects 20 to 40% of infants. This note explains the post-prandial mast cell mechanism and what the maternal PMCHS terrain changes in the equation.
Read the note →