Thank you to each and every one of you. What you shared with us confirms what many felt for years without being able to name it.
This preprint presents the PMCHS theoretical framework — a syndrome of epigenetically programmed mast cell hyperreactivity, transmitted predominantly along the maternal line, amplified by adverse childhood experiences and perinatal history. It integrates survey data (N=423), a literature review (86+ references), and an original mechanistic model centred on the NR3C1/KITLG axis.
42.1% report exclusively maternal transmission. The maternal-to-paternal ratio is 5.4:1 — consistent with epigenetic inheritance along the maternal line. Only 7.8% report exclusively paternal transmission.
77.4% of respondents who answered this item report significant stressful or traumatic events during childhood (ages 0–18) — converging with scientific data on HPA axis programming and mast cell reactivity via NR3C1.
94.8% experienced difficulties before receiving appropriate care. 80.9% went through years of diagnostic odyssey or still have no adequate care. 94.5% have never had their urinary histamine measured.
68.8% of parent respondents report that their children present with similar conditions (clearly or partially). 9.7% report a SIDS history in their family or close circle — a signal warranting formal investigation.
These findings support the hypothesis of a Programmed Mast Cell Hyperreactivity Syndrome (PMCHS) — a heritable terrain, transmitted predominantly along the maternal line, amplified by perinatal history and life stress, expressing itself across a spectrum of conditions long treated in isolation. The term"idiopathic" — meaning without known cause — no longer reflects what the data shows.